Clinical studies

In multiple clinical studies, treatment with Collagenase SANTYL◊ Ointment (in conjunction with sharp debridement) has resulted in faster reduction of wound area.12-14,17

Mode of Action references

  1. Loveluck J, et al. ePlasty. 2016;16:183-195.
  2. Galiano RD, et al. PlastReconstr Surg Glob Open. 2018;6(1):e1560.
  3. Pellino G, et al. Surg Innov. 2014;21(2):204–212.
  4. Kilpadi DV, et al. Wound Repair Regen. 2011;19(5):588-596.
  5. Malmsjö M, et al. ePlasty. 2014;14:1-15.
  6. Ma Z, et al. Exp Ther Med. 2016;11(4):1307-1317.
  7. Xia CY, et al. Mol Med Rep. 2014;9(5):1749-1754.
  8. Birke-Sorensen H, et al.. Journal of plastic, reconstructive and aesthetic surgery: JPRAS 64 Suppl, S1–S16 (2011)
  9. Scalise A, et al. Int Wound J. 2016;13:1260–1281.
  10. Shim HS, et al. Biomed Res Int. 2018;2018
  11. R. G, R. D, J. S, et al. The effects of a single use canister-free Negative Pressure Wound Therapy (NPWT) System* on the prevention of post surgical wound complications in patients undergoing bilateral breast reduction surgery. Paperpresented at: The British Association of Aesthetic Plastic Surgeons (BAAP's) 30th Annual Scientific Meeting; 2014; London.
  12. Hudson DA, Adams KG, Van Huyssteen A, Martin R, Huddleston EM. Simplified negative pressure wound therapy: clinical evaluation of an ultraportable, no-canister system. Int Wound J. 2015;12(2):195-201.
  13. Kirsner R, Dove C, Reyzelman A, Vayser D, Jaimes H. A Prospective, Randomised, Controlled Clinical Trial on the Efficacy of a single-use Negative Pressure Wound Therapy System, compared to Traditional Negative Pressure Wound Therapy in the Treatment of Chronic Ulcers of the Lower Extremities. Wound Repair Regen. 2019;27(5):519 - 529.
  14. Smith+Nephew 2018.Summary of rountine QA testing on MVP of PICO dressings. 2018. Internal Report. DS/18/153/R.
  15. Smith+Nephew 2019.Use of Moisture Vapour Permeability* (MVP) and Moisture Vapour Transmission rate** (MVTR) data to support product claims referring to moist wound healing. Internal Report. EO.AWM.PCSgen.001.v2.

PICO active incision management references

  1. Malmsjö M, Huddleston E, Martin R. Biological Effects of a Disposable, Canisterless Negative Pressure Wound Therapy System. ePlasty. 2014;14:1 - 15
  2. Hudson DA, Adams KG, Van Huyssteen A, Martin R, Huddleston EM. Simplified negative pressure wound therapy: clinical evaluation of an ultraportable, nocanister system. Int Wound J. 2015;12(2):195-201.
  3. Payne C, Edwards D. Application of the Single Use Negative Pressure Wound Therapy Device (PICO) on a Heterogeneous Group of Surgical and Traumatic Wounds. ePlasty. 2014:152-166.
  4. Stryja J, Staffa R, Říha D, Stryjová K, Nicielniková K. Cost-effectiveness of negative pressure wound therapy in outpatient setting. Prolekare. 2015;94(8):322 - 328.
  5. Smith+Nephew November 2018.The Review Of Evidence Supporting The Use Of PICO In Wounds ≥2cm In Depth. Internal Report. EO.AWM.PCS230.001.v2.
  6. Casey C. Consistent delivery of therapeutic negative pressure levels by a singleuse negative pressure wound therapy system (sNPWT)* in a wound model. Paper presented at: EWMA; 2019; Gothenburg, Sweden
  7. Smith+Nephew January 2019.Air Leak Tolerance Report: A comparison of PICO v2 (PICO 7 and PICO 14) Devices to PICO vl.6 (PlCO) Devices. Internal Report. RD/19/006.
  8. Smith+Nephew December 2018.PICO 14 Service Life Testing: 14 Day Device Lifespan. Internal Report. RD/18/132.
  9. Smith+Nephew 2021.PICO™ Pressure Mapping Study. Internal Report. DS/19/211/R - Part B.
  10. Smith+Nephew July 2018.PICO 7Y Non-NPWT Wound Model Summary. Internal Report. DS.18.260.R.
  11. Smith+Nephew 2020.Bacterial barrier testing of the PICO dressing. Internal Report. 2001002.
  12. Smith+Nephew 2018.Summary of rountine QA testing on MVP of PICO dressings. 2018. Internal Report. DS/18/153/R.
  13. Gilchrist B, Robinson M, Jaimes H. Performance, safety, and efficacy of a single use negative pressure wound therapy system for surgically closed incision sites and skin grafts: A prospective multi-centre follow-up study. Paper presented at: SAWC; 2020; Virtual
  14. Sharpe A, Myers D, Searle R. Using single use negative pressure wound therapy for patients with complicated diabetic foot ulcers: an economic perspective. Wounds UK. 2018;14(3):80-137.
  15. Myers D, Sharpe A. EP549 Service Delivery in Complex DFU Patients using Single Use NPWT - A UK Perspective. Paper presented at: EWMA; 2018; Krakow.

General references

  1. Najjar PA, et al. Surg Clin N Am 2015;95(2):269-283. World Union of Wound Healing Societies (WUWHS). Consensus Document: Closed surgical incision management: Understanding the role of NPWT. https://woundsinternational.com/world-union-resources/closed-surgical-incision-managementunderstanding-the-role-of-npwt/. 
  2. Merkow, R, et al. JAMA, February 3, 2015, Volume 313, Number 5.
  3. Nussbaum SR, et al. An. Value Health. 2018 Jan;21(1):27-32.
  4. Olsen et al. J Am Coll Surg. 2008 Sep;207(3):326-35.
  5. Olsen MA, et al. Archives of Surgery. 2008 Jan 1;143(1):53-60.  
  6. Cotogni P, et al. J Crit Care Med 2015;4(4): 265-273.
  7. Jenks PJ, et al. Journal of Hospital Infection, 2014; 86(1), pp.24-33.  
  8. Tanner J, et al. Journal of Hospital Infection. 2009 Jul 1;72(3):243–50.
  9. Aicher B, et al. Journal of Vascular Nursing. 2017 Sep 1;35(3):146–56.
  10. Gwilym BL, et al. European Journal of Vascular and Endovascular Surgery. 2021 Jan 7.
  11. Smith+Nephew 2018. Internal Report. DS.18.260.R.
  12. Stryja J, et al. Prolekare. 2015;94(8):322 - 328.
  13. Smith+Nephew 2015. Internal Report. ST865 CT09/02.
  14. Hudson DA, et al. Int Wound J. 2015;12(2):195-201.
  15. Payne C, et al. ePlasty. 2014:152-166.
  16. Malmsjö M, et al. ePlasty. 2014;14:1 - 15.
  17. Casey C. Consistent delivery of therapeutic negative pressure levels by a single use negative pressure wound therapy system (sNPWT)* in a wound model. Paper presented at: EWMA; 2019; Gothenburg, Sweden.
  18. Smith+Nephew 2019. Internal Report. RD/19/006.
  19. Smith+Nephew 2020. Internal Report. 2001002.
  20. Smith+Nephew 2018. Internal Report. RD/18/132.
  21. Smith+Nephew 2018. Internal Report. DS/18/219/R V2.
  22. Mcmanus H, et al. Bacterial retention within a multi-layered absorbent AIRLOCK™ Technology Single Use Negative Pressure Wound Therapy (sNPWT) dressing. Paper presented at: EWMA; 2018; Krakow, Poland.
  23. Loveluck J, et al. ePlasty. 2016;16:183-195.
  24. Kilpadi DV, et al. Wound Repair Regen. 2011;19(5):588-596.
  25. Birke-Sorensen H, et al.. Journal of plastic, reconstructive and aesthetic surgery: JPRAS 64 Suppl, S1–S16 (2011)
  26. Scalise A, et al. Int Wound J. 2016;13:1260–1281.
  27. Shim HS, et al. Biomed Res Int. 2018;2018
  28. Fleming CA, et al. J Hosp Infect. 2018;99(1):75–80.
  29. Gillespie BM, et al. Surg Innov. 2015;22(5):488–495.
  30. Galiano RD, et al. PlastReconstr Surg Glob Open. 2018;6(1):e1560.
  31. Pellino G, et al. Surg Innov. 2014;21(2):204–212.
  32. Pellino G, et al. Int J Surg. 2014;12 Suppl 2:S64–S68.
  33. Selvaggi F, et al. Surg Technol Int. 2014;24:83–89.
  34. Ma Z, et al. Exp Ther Med. 2016;11(4):1307-1317.
  35. Xia CY, et al. Mol Med Rep. 2014;9(5):1749-1754.
  36. Groenen H, et al. eClinicalMedicine (part of The Lancet group). 2023;62:102105.
  37. Bullough L, et al. The Clinical Services Journal. 2015:2-6.
  38. Hyldig N, et al. BJOG. 2019;126(5):619-627.
  39. Karlakki SL, et al. Bone Joint Res. 2016;5(8):328-337.
  40. Nherera LM, et al. Wound Repair Regen. 2017;25(3):474-482.
  41. Saunders C, et al. BJS Open. 2021;0(0):1 - 8.
  42. Holt R, et al. British Journal of Hospital Medicine. 2015;76(4). 43.
  43. O’Leary DP, et al. Ann Surg. 2017;265(6):1082–1086.       
  44. Hudson DA, et al. International wound journal, 2015; 12(2), pp.195-201.   
  45. Witt-Majchrzak A, et al. Pol PrzeglChir. 2015;86(10):456-465.
  46. Fleming CA, et al. J Hosp Infect. 2018; 99:75–80.
  47. Smith+Nephew 2016. Internal report. DS.16.179.R.
  48. Smith+Nephew 2016. Internal report. DS.16.174.R.
  49. Smith+Nephew 2008. Internal report. DS/08/062/R1.
  50. Smith+Nephew 2009. Internal report. DS/08/078/R2.
  51. Smith+Nephew 2008. Internal report. DS/08/062/R2.
  52. Smith+Nephew 2017. Internal report. DS/16/363/R2.
  53. Smith+Nephew 2019. Internal Report. EO.AWM.PCSgen.001.v2.
Approved Uses
Important Safety Information

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