Previous studies have shown17, 22 the positive outcomes when using SANTYL Ointment in conjunction with other wound care products. To ensure that the collagenase enzyme in SANTYL maintains activity, in vitro testing was performed across a wide variety of commonly used products to determine compatibility. Testing did not evaluate efficacy, only the ability of collagenase to remain active and functional.
An inhibition level of 20% or less is deemed an acceptable threshold for enzymatic activity when used concomitantly with topical adjunctive therapies.25
If inhibition levels exceed 20%, collagenase enzyme activity and efficacy may be affected.
These results are from in vitro studies and are only an approximation of actual therapeutic outcomes. The decision to use a wound care product or combination of products should rest on a clinical judgement in which the perceived benefits outweigh any potential risks.
For detailed product information, including indications for use, contraindications, effects, precautions, warnings, and important safety information, please consult each product's Instructions for Use (IFU) prior to use.
Mode of Action references
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- Gilchrist B, Robinson M, Jaimes H. Performance, safety, and efficacy of a single use negative pressure wound therapy system for surgically closed incision sites and skin grafts: A prospective multi-centre follow-up study. Paper presented at: SAWC; 2020; Virtual
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- Wang E, Tang R, Walsh N, et al. Topical negative pressure therapy and compression in the management of venous leg ulcers: a pilot study. Wound Practice and Research 2017;25(1):36-40.
- Smith+Nephew 2020.Negative Pressure Wound Therapy and Pressure Garment Therapy. Internal Report. EO.AWM.PCS261.002.v2.
General references
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- Nursery research - TSO
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